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Serotonin–glutamate and serotonin–dopamine reciprocal interactions as putative molecular targets for novel antipsychotic treatments: from receptor heterodimers to postsynaptic scaffolding and effector proteins

Abstract  The physical and functional interactions between serotonin–glutamate and serotonin–dopamine signaling have been suggested
to be involved in psychosis pathophysiology and are supposed to be relevant for antipsychotic treatment. Type II metabotropic
glutamate receptors (mGluRs) and serotonin 5-HT2A receptors have been reported to form heterodimers that modulate G-protein-mediated intracellular signaling differentially
compared to mGluR2 and 5-HT2A homomers. Additionally, direct evidence has been provided that D2 and 5-HT2A receptors form physical heterocomplexes which exert a functional cross-talk, as demonstrated by studies on hallucinogen-induced
signaling. Moving from receptors to postsynaptic density (PSD) scenario, the scaffolding protein PSD-95 is known to i…

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