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Human pharmacology of 3,4-methylenedioxymethamphetamine (MDMA, ecstasy) after repeated doses taken 2 h apart

Conclusions  MDMA pharmacokinetics and metabolic disposition following two doses separated by 2 h show that the contribution of the first
dose to the MDMA-induced mechanism-based metabolic inhibition was already apparent. The concentrations of MDMA after the second
dose were slightly higher than expected. The effects on blood pressure and temperature after the second administration were
slightly higher than those following the first, but for heart rate and subjective variables these were lower than expected
considering the MDMA concentrations achieved, suggesting a possible tolerance phenomenon.

Content Type Journal ArticleCategory Original InvestigationPages 1-11DOI 10.1007/s00213-012-2894-7Authors
A. M. Peiró, Human Pharmacology and Clinical Neurosciences R…

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Latest NewsNewsTaking Pills

Human pharmacology of 3,4-methylenedioxymethamphetamine (MDMA, ecstasy) after repeated doses taken 2 h apart

Conclusions  MDMA pharmacokinetics and metabolic disposition following two doses separated by 2 h show that the contribution of the first
dose to the MDMA-induced mechanism-based metabolic inhibition was already apparent. The concentrations of MDMA after the second
dose were slightly higher than expected. The effects on blood pressure and temperature after the second administration were
slightly higher than those following the first, but for heart rate and subjective variables these were lower than expected
considering the MDMA concentrations achieved, suggesting a possible tolerance phenomenon.

Content Type Journal ArticleCategory Original InvestigationPages 1-11DOI 10.1007/s00213-012-2894-7Authors
A. M. Peiró, Human Pharmacology and Clinical Neurosciences R…

Read more 0 Comments