Pharmacologic evidence to support clinical decision making for peripartum methadone treatment

Conclusions  Most women require increases in methadone dose across pregnancy. Given the shorter half-life and larger clearances during pregnancy, many pregnant women may benefit from split methadone dosing. L/D increases quickly after delivery and doses should be lowered rapidly after delivery. Content Type Journal ArticleCategory Original InvestigationPages 1-11DOI 10.1007/s00213-012-2833-7Authors D. L. Bogen, Department of Pediatrics, Division of General Academic Pediatrics, Children’s Hospital of Pittsburgh, University of Pittsburgh School of Medicine, 3414 Fifth Ave, CHOB 3rd floor, Pittsburgh, PA 15213, USAJ. M. Perel, Department of Psychiatry, Western Psychiatric Institute and Clinic, University of Pittsburgh School of Medicine, Pittsburgh, PA, USAJ. C. Helse...


Conclusions  Most women require increases in methadone dose across pregnancy. Given the shorter half-life and larger clearances during
pregnancy, many pregnant women may benefit from split methadone dosing. L/D increases quickly after delivery and doses should
be lowered rapidly after delivery.

Content Type Journal ArticleCategory Original InvestigationPages 1-11DOI 10.1007/s00213-012-2833-7Authors
D. L. Bogen, Department of Pediatrics, Division of General Academic Pediatrics, Children’s Hospital of Pittsburgh, University of Pittsburgh School of Medicine, 3414 Fifth Ave, CHOB 3rd floor, Pittsburgh, PA 15213, USAJ. M. Perel, Department of Psychiatry, Western Psychiatric Institute and Clinic, University of Pittsburgh School of Medicine, Pittsburgh, PA, USAJ. C. Helse…

Pharmacologic evidence to support clinical decision making for peripartum methadone treatment

Conclusions  Most women require increases in methadone dose across pregnancy. Given the shorter half-life and larger clearances during pregnancy, many pregnant women may benefit from split methadone dosing. L/D increases quickly after delivery and doses should be lowered rapidly after delivery. Content Type Journal ArticleCategory Original InvestigationPages 1-11DOI 10.1007/s00213-012-2833-7Authors D. L. Bogen, Department of Pediatrics, Division of General Academic Pediatrics, Children’s Hospital of Pittsburgh, University of Pittsburgh School of Medicine, 3414 Fifth Ave, CHOB 3rd floor, Pittsburgh, PA 15213, USAJ. M. Perel, Department of Psychiatry, Western Psychiatric Institute and Clinic, University of Pittsburgh School of Medicine, Pittsburgh, PA, USAJ. C. Helse...


Conclusions  Most women require increases in methadone dose across pregnancy. Given the shorter half-life and larger clearances during
pregnancy, many pregnant women may benefit from split methadone dosing. L/D increases quickly after delivery and doses should
be lowered rapidly after delivery.

Content Type Journal ArticleCategory Original InvestigationPages 1-11DOI 10.1007/s00213-012-2833-7Authors
D. L. Bogen, Department of Pediatrics, Division of General Academic Pediatrics, Children’s Hospital of Pittsburgh, University of Pittsburgh School of Medicine, 3414 Fifth Ave, CHOB 3rd floor, Pittsburgh, PA 15213, USAJ. M. Perel, Department of Psychiatry, Western Psychiatric Institute and Clinic, University of Pittsburgh School of Medicine, Pittsburgh, PA, USAJ. C. Helse…

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